The prevalence of polycystic ovary syndrome in adolescents: A systematic review and meta-analysis|
Naz, Marzieh Saei Ghare; Tehrani, Fahimeh Ramezani; Majd, Hamid Alavi; Ahmadi, Fazlollah; Ozgoli, Giti; Fakari, Farzaneh Rashidi & Ghasemi, Vida
Background: Polycystic ovarian syndrome is an endocrine disorder with many
complications. This syndrome is a growing concern among adolescents around the
world, with varying reports of its prevalence in different parts of the world.
Objective: This study aimed to determine the prevalence of polycystic ovary syndrome
in adolescents by a systematic review and meta-analysis.
Materials and Methods: In this study, a search for published articles with an English
language limitation and without a time limit was done in different databases (Scopus,
PubMed, and Web of Science, Emabse and Cochrane) in January 2019. The 12 studies
that met the criteria for entering a qualitative assessment scale of 5 and higher were
subjected to systematic review and meta-analysis. Egger and Begg’s tests were used
to check the publication bias. Data were analyzed with STATA software, version 11.1.
Results: Twelve studies were included for meta-analysis. The total number of
participants in the study was 149,477. The average quality score of all studies was 8.67
(range: 5–10). The prevalence of polycystic ovarian syndrome in adolescents based
on the Rotterdam criteria was 11.04% (95% CI: 6.84–16.09%), based on the National
Institute of Health criteria, it was 3.39% (95% CI: 0.28–9.54%), and based on Androgen
Excess and Polycystic Ovary Syndrome Society, it was 8.03% (95% CI: 6.24–10.01%)
Conclusion: The result of this study showed that there is a variation in the prevalence
of PCOS in adolescents based on different criteria; we suggest more community-based
studies among adolescences in different parts of the world.
Polycystic ovary syndrome; Prevalence; Meta-analysis; Adolescence.