International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
Vol. 17, No. 7, 2019, pp. 487-492
Bioline Code: rm19052
Full paper language: English
Document type: Research Article
Document available free of charge
International Journal of Reproductive BioMedicine, Vol. 17, No. 7, 2019, pp. 487-492
© Copyright 2019 - Mujde Can Ibanoglu et al.
Maternal plasma fetuin-A levels in fetal growth restriction: A case-control study|
Ibanoglu, Mujde Can; Sanhal, Cem Yasar; Ozgu-Erdinc, Seval; Kara, Ozgur; Yucel, Aykan & Uygur, Dilek
Background: Higher Fetuin-A (FA) concentrations were found to be associated with
obesity and there is an interest to the relation between maternal FA and pregnancy
Objective: In this study, our aim was to evaluate the association of maternal plasma
levels of FA with fetal growth restriction (FGR).
Materials and Methods: 41 pregnant women with FGR and 40 controls were recruited
in this case-control study between July and November 2015. At the diagnosis of FGR,
venous blood samples (10 cc) were obtained for FA analysis.
Results: Maternal plasma FA levels were significantly higher in fetal growth-restricted
pregnant women compared with controls (19.3 ± 3.0 ng/ml vs 25.9 ± 6.8 ng/ml, p =
0.001). Area under receiver operating characteristic curve analysis of FA in FGR was
0.815 (95% confidence interval (CI): 0.718-0.912, p < 0.001). The maternal FA levels
with values more than 22.5 ng/ml had a sensitivity of about 73.17% (95% CI: 56.79-85.25) and a specificity of about 82.5% (95% CI: 66.64-92.11) with positive and negative
predictive values of about 81.08% (95% CI: 64.29-91.45) and 75% (95% CI: 59.35-86.30),
respectively. Therefore, the diagnostic accuracy was obtained about 77.78%.
Conclusion: The results of this study show higher maternal plasma levels of FA in
FGR. Further studies are needed in order to demonstrate the long-term effects of FA
in pregnancies complicated with FGR and early prediction of FGR.
Fetal growth restriction; Fetuin-A; Pregnancy
Alternative site location: http://www.ijrm.ir