International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
Vol. 17, No. 6, 2019, pp. 425-434
Bioline Code: rm19045
Full paper language: English
Document type: Research Article
Document available free of charge
International Journal of Reproductive BioMedicine, Vol. 17, No. 6, 2019, pp. 425-434
© Copyright 2019 - Mehran Dorostghoal et al.
Beneficial effects of Cichorium intybus L. extract on oxidative status and reproductive parameters in male Wistar rats: An experimental study|
Dorostghoal, Mehran; Seyyednejad, Seyyed Mansour & Nejad, Marzieh Noroozi Tabrizi
Background: During recent years, increasing concern has been raised about the
declining sperm count and human male infertility. Cichorium intybus L. (C. intybus) has
traditionally been used in Iranian folk medicine as hepato protective and blood purifier
and for its presumed fertility-enhancing properties.
Objective: A dose-response study was performed to determine the effect of C. intybus
ethanolic leave extract on the reproductive parameters in adult Wistar male rats.
Materials and Methods: In this experimental study, 40 healthy adult male Wistar rats
(8 wk old, 200-210 gr body weight) were randomly divided (n = 10/each) as control
and groups treated with 50, 100, and 200 mg/kg/day of C. intybus extract via gavage
for 70 days. Serum hormonal assay, epididymal sperm evaluation, and analysis of
morphometrical parameters, antioxidant enzymes, and lipid peroxidation levels of testis
were done in each experimental group.
Results: Weights of testis and epididymis increase significantly in male rats treated
with 200 mg/kg C. intybus extract. Sperm density and percent of morphologically
normal sperm were significantly increased in a dose-related manner with C. intybus
treatment.Serum testosterone was higher at 100 and 200 mg/kg C. intybus extract-treated
groups. C. intybus significantly reduced malondialdehyde levels and also
increased superoxide dismutase and glutathione peroxidase activity in testicular tissue
Conclusion: It is concluded that C. intybus leave extract improves reproductive
parameters in male rats which might be a consequence of both its antioxidant and
Spermatogenesis; Oxidativestress; Rat; Cichorium intybus L.
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