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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433
EISSN: 2008-2177
Vol. 17, No. 5, 2019, pp. 303-314
Bioline Code: rm19033
Full paper language: English
Document type: Review Article
Document available free of charge

International Journal of Reproductive BioMedicine, Vol. 17, No. 5, 2019, pp. 303-314

 en Interleukins in diagnosis of perinatal asphyxia: A systematic review
Boskabadi, Hassan; Moradi, Ali & Zakerihamidi, Maryam


Background: Biochemical markers including interleukins (ILs) has been proposed for early diagnosis of asphyxia.
Objective: This study has aimed to systematically review the significance of IL measurements in the diagnosis of perinatal asphyxia.
Materials and Methods: PubMed, Cochrane Library, Web of Science, Embase, and Scopus databases before 2017 were searched for the following keywords: asphyxia, neonatal, interleukin, and diagnosis. A total of 13 out of 300 searched papers were finally selected for evaluation. Interleukins under study were IL6 and interleukin 1𝛽 (IL-1𝛽). Interleukins had been measured in 10 studies by serum samples, 2 studies by samples of Cerebro Spinal Fluid (CSF), and 1 study by sample of umbilical cord blood. The inclusion criteria were: studies on neonates, with adequate information from the test results and studies using markers other than ILs to detect asphyxia; however, studies with only abstracts available were excluded.
Results: Research on the issue suggests that IL6 > 41 Pg/dl has the sensitivity of 84.88% and the specificity of 85.43%, whereas IL-1𝛽 > 4.7 Pg/dl has the sensitivity of 78% and specificity of 83% in the diagnosis of neonatal asphyxia. Among diagnostic ILs for neonatal asphyxia, combination of IL6 and IL-1𝛽 had the highest sensitivity, that is, 92.9%.
Conclusion: IL6 and IL-1𝛽 of serum samples were used in the early diagnosis of perinatal asphyxia and are useful predictors for the outcomes of perinatal asphyxia and its intensity. In addition, simultaneous evaluation of IL-1𝛽 and IL6 can improve the sensitivity of the early diagnosis of perinatal asphyxia.

Diagnosis; Interleukins; Asphyxia neonatorum.

© Copyright 2019 - Hassan Boskabadi et al.
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