Interleukins in diagnosis of perinatal asphyxia: A systematic review|
Boskabadi, Hassan; Moradi, Ali & Zakerihamidi, Maryam
Background: Biochemical markers including interleukins (ILs) has been proposed for
early diagnosis of asphyxia.
Objective: This study has aimed to systematically review the significance of IL
measurements in the diagnosis of perinatal asphyxia.
Materials and Methods: PubMed, Cochrane Library, Web of Science, Embase, and
Scopus databases before 2017 were searched for the following keywords: asphyxia,
neonatal, interleukin, and diagnosis. A total of 13 out of 300 searched papers were
finally selected for evaluation. Interleukins under study were IL6 and interleukin 1𝛽
(IL-1𝛽). Interleukins had been measured in 10 studies by serum samples, 2 studies by
samples of Cerebro Spinal Fluid (CSF), and 1 study by sample of umbilical cord blood.
The inclusion criteria were: studies on neonates, with adequate information from the
test results and studies using markers other than ILs to detect asphyxia; however,
studies with only abstracts available were excluded.
Results: Research on the issue suggests that IL6 > 41 Pg/dl has the sensitivity of 84.88%
and the specificity of 85.43%, whereas IL-1𝛽 > 4.7 Pg/dl has the sensitivity of 78%
and specificity of 83% in the diagnosis of neonatal asphyxia. Among diagnostic ILs
for neonatal asphyxia, combination of IL6 and IL-1𝛽 had the highest sensitivity, that is,
Conclusion: IL6 and IL-1𝛽 of serum samples were used in the early diagnosis of
perinatal asphyxia and are useful predictors for the outcomes of perinatal asphyxia
and its intensity. In addition, simultaneous evaluation of IL-1𝛽 and IL6 can improve the
sensitivity of the early diagnosis of perinatal asphyxia.
Diagnosis; Interleukins; Asphyxia neonatorum.