International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
Vol. 17, No. 4, 2019, pp. 253-260
Bioline Code: rm19027
Full paper language: English
Document type: Research Article
Document available free of charge
International Journal of Reproductive BioMedicine, Vol. 17, No. 4, 2019, pp. 253-260
© Copyright 2019 - Shiva Hadadianpour et al.
Immediate dilation of a tight or stenotic cervix by intra-procedural administration of hyoscine butylbromide: A clinical trial|
Hadadianpour, Shiva; Tavana, Shahrzad; Tavana, Anahita & Fallahian, Masoumeh
Background: Cervical dilation is indicated prior to performing various gynecological
procedures. However, gynecologists are at times confronted with a stenotic or tight
cervix, resistant to dilation. This can be problematic particularly when cervical ripening
has not been attempted hours before the start of the procedure.
Objective: The objective of this study is to investigate the efficacy of administration of
hyoscine butylbromide for cervical dilation for immediate dilation of the tight or stenotic
Materials and Methods: In this clinical trial study, a population of 40 women, aged
20-70 yr with stenotic cervix, evidenced by resistance to pass dilator #2 through their
cervical canal were compared. Cervical patency was assessed 10 min following intracervical
canal instillation of hyoscine butylbromide.
Results: Cervical width of 57.5% of patients became wider, as evidenced by passage of
the number 4 Hegar dilator through the cervical canal without resistance. Independent
T-tests did not reveal any statistically significant difference between the two groups
based on their age. Fisher Exact test revealed a statistically significant difference
between the two groups based on the prior route of delivery, with a more statistically
significant response in patients who had vaginal deliveries.
Conclusion: Intra-cervical canal instillation of hyoscine butylbromide is effective in
immediate dilation of the tight or stenotic cervix during intra-uterine procedures.
Hyoscine butylbromide; Cervical dilatation; Cervical ripening.
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