International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
Vol. 17, No. 3, 2019, pp. 201-208
Bioline Code: rm19022
Full paper language: English
Document type: Research Article
Document available free of charge
International Journal of Reproductive BioMedicine, Vol. 17, No. 3, 2019, pp. 201-208
© Copyright 2019 - Zohreh Rahimi et al.
The CYP17 MSP AI (T-34C) and CYP19A1 (Trp39Arg) variants in polycystic ovary syndrome: A case-control study|
Rahimi, Zohreh & Mohammadi, Ehsan
Background: Polycystic ovary syndrome (PCOS) is a common and chronic disorder
of endocrine glands where genetic factors play a major role in the susceptibility to
the disease. The cytochrome (CYP) 17 enzyme is essential for androgens biosynthesis.
Also, the CYP19 enzyme converts the androgens to the aromatic estrogens.
Objective: We aimed to investigate the association of CYP 17 MSP AI (T-34C) and CYP
19A1 (Trp39Arg) variants with the pathogenesis of PCOS in a population from Western
Iran with Kurdish ethnic background.
Materials and Methods: The present case-control study consisted of 50 patients with
PCOS and 109 controls. The CYP17 T-34C and CYP19A1 (Trp39Arg) polymorphisms
were identified by polymerase chain reaction-restriction fragment length polymorphism.
The serum lipid and lipoprotein profile were detected by the Bionic Diagnostic
Kits. Estradiol, dehydroepiandrosterone (DHEA), and sex hormone-binding globulin
(SHBG) levels were measured using the chemiluminescent method.
Results: The serum levels of estradiol and SHBG in PCOS patients were lower than
controls (p < 0.001 and p = 0.06, respectively). However, the level of DHEA was higher (p
= 0.01) in patients compared to controls. The higher frequency of CYP17 TC genotype in
patients (30%) compared to controls (15.6%) was associated with 2.31-fold susceptibility
to PCOS (p = 0.038). The frequency of CYP19 TC genotype was 6.4% in controls and
10% in patients (p = 0.42).
Conclusion: The present study suggests that CYP17 TC genotype could be associated
with the risk of PCOS. Also, the study indicated the sex steroid hormones level
alteration and the lower level of SHBG in PCOS patients compared to healthy
Cytochrome 17 (T-34C); Cytochrome 19 (Trp39Arg); Polycystic ovary syndrome; Sex steroid hormones; Sex hormone-binding globulin.
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