The comparison of depression and anxiety between fertile and infertile couples: A meta-analysis study|
Fallahzadeh, Hossein; Abadi, Hasan Zareei Mahmood; Momayyezi, Mahdieh; Moghadam, Hakimeh Malaki & Keyghobadi, Naeimeh
Background: Depression and anxiety are the most common reaction in infertile
couples. Several studies have been conducted to examine the psychiatric disorders
among infertile and fertile couples.
Objective: This meta-analysis was conducted to compare the depression and anxiety
in fertile and infertile couples in various studies.
Materials and Methods: The authors searched articles published in multiple databases
including World Health Organization, PubMed, Cochrane Library, Scopus, Science
Direct, Medline EMBASE and Persian databases including Scientific Information
Database (SID) and IranMedx between 2005 and 2017. The main keywords used for
searching the databases were: depression, anxiety, infertility, and fertility. Statistical
analyses were performed using Comprehensive Meta-Analysis/2.0 software.
Results: The authors found 42 related articles after searching the databases. 11 articles
entered the meta-analysis after considering the inclusion and exclusion criteria. Finally,
eight articles were chosen for the comparison of depression and anxiety, two published
articles for the comparison of depression, and one published article to compare anxiety
in fertile and infertile couples. The results of the heterogeneity test showed a significant
heterogeneity among all articles that were analyzed in this meta-analysis in the field
of depression and anxiety. The results showed that depression (p = 0.0001; Hedges’g
= 1.21; 95% CI 0.63–1.78) and anxiety (p = 0.00001; Hedges’g = 0.63; 95% CI 0.54–0.73) were higher in infertile couples than fertile couples and that the possibility of a
publication bias does not exist in this study.
Conclusion: The analysis of articles used in this meta-analysis showed that depression
and anxiety scores in infertile couples were higher than fertile couples.
Depression; Anxiety; Infertility; Meta-analysis.