The relationship between maternal vitamin D status during third trimester of pregnancy and maternal and neonatal outcomes: A longitudinal study|
Shakeri, Mahboobeh & Jafarirad, Sima
Background: Vitamin D deficiency is a common nutritional concern and leads to
several problems among some population groups.
Objective: The aim of the current study was to evaluate the relationship between
maternal vitamin D status and gestational weight gain, maternal biochemical parameters,
mode of delivery, and infants’ growth indices at birth.
Materials and Methods: A longitudinal study between March and June 2017 was
carried on 82 mothers in Ahvaz. Blood samples of each mother were obtained at the
mean of the third trimester to assay lipid indices (total cholesterol, triglycerides, lowdensity
lipoprotein, and high-density lipoprotein cholesterol), fasting blood sugar, and
25-hydroxy vitamin D. Anthropometric assessment of newborns was recorded from
neonatal health card at birth.
Results: Mean maternal 25-hydroxy vitamin D level was 22.52 nmol/L; 7.33% of mothers
had vitamin D deficiency, 76.6% had vitamin D insufficiency, and 15.9% were normal.
The mean neonate birth weight, length, and head circumference of mothers who were
on the third tercile of 25-hydroxy vitamin D serum level was significantly higher than
those in the first tercile (p < 0.001, p = 0.004 and p < 0.001, respectively). Maternal
vitamin D serum level had an adverse relationship with fasting blood sugar.
Conclusion: Low levels of serum vitamin D may cause adverse pregnancy outcomes
and delivery of infants with insufficient growth at birth.
Vitamin D; Pregnancy; Infant; Growth; Delivery; Blood glucose.