Body fat percentage is a better marker than body mass index for determining inflammation status in polycystic ovary syndrome|
Hestiantoro, Andon; Hasani, Rachmat Dediat Kapnosa; Shadrina, Amalia; Situmorang, Herbert; Ilma, Nurul; Muharam, Raden; Sumapraja, Kanadi & Wiweko, Budi
Background: Polycystic ovary syndrome (PCOS) is an endocrinopathic disorder
most commonly experienced by women of reproductive age, and it is characterized
by a low-grade chronic inflammatory condition. Excessive fat deposit has been long
considered as an etiological factor in the pathogenesis of this inflammatory
condition. Currently, body mass index (BMI) or percentage of body fat is used as a
marker to assess the body fat composition of a person.
Objective: To determine whether BMI or body fat percentage (BFP) can be used as
a better marker for measuring inflammation related to body fat accumulation in
polycystic ovary syndrome patients.
Materials and Methods: This study took place at the Center for Reproductive
Medicine, Yasmin Clinic, Cipto Mangunkusumo Hospital from January to
December 2015. In this cross-sectional study, 32 reproductive age women with
PCOS according to the Rotterdam criteria (2003) participated. Women with
hyperandrogenism caused by non-classic congenital adrenal hyperplasia, pregnant
and lactating women, etc., were excluded. Some variables such as BMI, clinical
hyperandrogenism sign, BFP, and inflammatory markers were assessed and
Results: From a total of 32 subjects of the study, BFP had a significant positive
correlation with procalcitonin levels (r=0.35; p=0.048), while BMI did not (r=0.27;
Conclusion: BFP can be used as a better marker for measuring inflammation related
to body fat accumulation in PCOS subjects.
Body fat; Body mass index; Inflammation; Polycystic ovary syndrome; Procalcitonin.