International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
Vol. 16, No. 9, 2018, pp. 557-562
Bioline Code: rm18066
Full paper language: English
Document type: Research Article
Document available free of charge
International Journal of Reproductive BioMedicine, Vol. 16, No. 9, 2018, pp. 557-562
© Copyright 2018 - International Journal of Reproductive BioMedicine
Mycobacterium tuberculosis and non-tubercular mycobacterium infection in women with unexplained infertility from eastern India|
Chatterjee, Tridip & Basak, Ashim Kumar
Background: Genital tuberculosis (GTB) is an important cause of female infertility,
especially in developing countries. The positive results of polymerase chain reaction
(PCR) in endometrial GTB in the absence of tubal damage raise the possibility of
the detection of sub-clinical or latent disease, with doubtful benefits of treatment.
Objective: This study aims to evaluate the Mycobacterium tuberculosis (MTB) and
Non-tubercular Mycobacterium (NTM) infection by using Real-PCR technique in
the menstrual blood samples of 120 unexplained infertile women.
Materials and Methods: In this cross-sectional study, 120 infertile women with
unexplained infertility aged 20-35 yr old and normal hysterosalpingography findings
were taken. Menstrual blood in the first 12 hr of menstruation containing the
endometrial tissues from each participant was tested for MTB and NTM by Real-Time PCR.
Results: Among the selected 120 patients, only two were found to be positive for
MTB infection. All remaining participants were negative for MTB infection. All
participants were negative for NTM infection at the endometrium.
Conclusion: Although, studies have indicated that PCR is a useful method in
diagnosing early GTB disease in infertile women with no demonstrable evidence of
tubal or endometrial involvement, our study showed that GTB is not the major
problem in women with unexplained infertility.
GTB; NTM; Real-time polymerase chain reaction; Unexplained infertility.
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