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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433
EISSN: 2008-2177
Vol. 16, No. 8, 2018, pp. 497-500
Bioline Code: rm18059
Full paper language: English
Document type: Research Article
Document available free of charge

International Journal of Reproductive BioMedicine, Vol. 16, No. 8, 2018, pp. 497-500

 en Antioxidant homeostasis is disturbed in fetuses with leptin-resistant genotypes: A cross-sectional study
Gonzalez-Añover, Pedro; Torres-Rovira, Laura; García-Contreras, Consolacion; Vazquez-Gomez, Marta; Pesantez, Jose Luis; Sanz-Fernandez, Maria Victoria; Astiz, Susana & Gonzalez-Bulnes, Antonio


Background: Leptin resistance is associated with lower reproductive efficiency, with deficiencies in embryo viability and growth leading to low prolificacy and high incidence of intrauterine growth restriction.
Objective: We aimed to investigate the underlying mechanisms of the leptin-resistance, evaluating the antioxidant homeostasis of leptin-resistant and lean swine fetuses.
Materials and Methods: The study included 70 plasma samples from fetuses at day 62 of gestation (mid-pregnancy), from breeds with (Iberian breed; n=35) and without leptin resistance (25% Large White x 25% Landrace x 50% Pietrain; n=35). The antioxidant status of the plasma samples was determined by photoinduced chemiluminescence whilst systemic oxidative stress was assessed determining plasma hydrogen peroxide concentration by enzimoimmunoassay.
Results: Plasma total antioxidant capacity was significantly lower in leptin-resistant fetuses (p=0.003), whilst systemic oxidative stress was increased (p=0.02).
Conclusion: Our results indicate key differences in the antioxidant status in pregnancies affected by leptin resistance.

Animal models; Fetus; Leptin; Oxidative stress; Pregnancy.

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