Protective effect of curcumin on fertility of rats after exposure to compact fluorescent lamps: An experimental study|
Khalaji, Naser; Namyari, Mahshid; Rasmi, Yousef; Pourjabali, Masoumeh & Chodari, Leila
Background: Testicular function is modified by maturational gonadostatic control
highly susceptible to negative physiologic niche-altering factors like UV-rays.
Objective: This study was performed in order to uncover new aspects of Compact
Florescent Lamps (CFLs) induced damages on the testicular tissue of rats and
evaluating the effect of curcumin on testis of rats after exposure to compact
Materials and Methods: Twenty-four adult male Albino rats were randomly
divided into three groups: control group (ethyl oleate 0.2 ml, IP, for 45 days, without
CFLs exposure), fluorescent group (ethyl oleate 0.2 ml, IP, daily and treated with 12
hr CFLs exposure for 45 days) and curcumin group (curcumin 20 μ M, IP along with
12 hr CFLs exposure for 45 days). The rats were anesthetized at the end of the
experiment. Gonadotropin hormones and prolactin levels were measured;
Histopathological and histomorphometrical analysis of the testis was carried out.
Results: Results of this study showed that CFLs significantly decreased serum
levels of follicle stimulating hormone, prolactin, testicular weight, sperm motility,
TDI, and SPI. Furthermore, CFLs had no effect on serum levels of luteinizing
hormone and sperm count and also, increased abnormal sperm shapes. Our results
also showed that curcumin supplementation following CFLs reversed these
Conclusion: These results strongly suggest that CFLs severely impairs testis while
curcumin as an antioxidant had protective effects on undesirable effects in testis
induced by CFLs.
Infertility; Compact fluorescent lamps; Curcumin; Rat.