International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
Vol. 16, No. 6, 2018, pp. 365-372
Bioline Code: rm18041
Full paper language: English
Document type: Research Article
Document available free of charge
International Journal of Reproductive BioMedicine, Vol. 16, No. 6, 2018, pp. 365-372
© Copyright 2018 - International Journal of Reproductive BioMedicine
Effects of antidepressants on parameters, melondiadehyde, and diphenyl-2-picryl-hydrazyl levels in mice spermatozoa|
Bandegi, Ladan; Anvari, Morteza; Vakili, Mahmood; Khoradmehr, Arezoo; Mirjalili, Aghdas & Talebi, Ali Reza
Background: Prescribing antidepressant drugs is becoming common. These drugs
are known to affect sexual functions.
Objective: The study is aimed to assess the effects of amitriptyline and venlafaxine
on sperm parameters and evaluate Malondialdehyde (MDA) and 1, 1-Diphenyl-2-picryl-hydrazyl values in BALB/ mice spermatozoa.
Materials and Methods: Forty adult male BALB/c mice were separated into five
groups. Group Ι (control) received distilled water; group ΙΙ amitriptyline (4 mg/kg);
group ΙΙΙ amitriptyline (4 mg/kg) +vitamin C (10 mg/kg); group ΙV venlafaxine (2
mg/kg); and group V received vitamin C (10 mg/kg) + venlafaxine (2 mg/kg). All
drugs were administered by oral gavage for 35 days. After excision of caudal
epididymis, it was located in 1 mL Ham's F10 medium at 37oC for 15 min and then
analysis of sperm parameters was performed. To examine lipid peroxidation and
total antioxidant capacity, the MDA and 1, 1-Diphenyl-2-picryl-hydrazyl were
Results: The mean sperm parameters in the group treated with amitriptyline were
significantly lower than in the other groups. MDA tests showed a significant
difference between amitriptyline and control groups (p=0.007).
Conclusion: The results of this study showed that amitriptyline consumption can
weaken sperm parameters, which can be attributed to the increased production of
ROS and toxicity resulting from amitriptyline consumption. Moreover, venlafaxine
improved sperm parameters in mice and the lipid peroxidation in this group did not
change compared to the control group.
Amitriptyline; Venlafaxine; MDA; Sperm chromatin.
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