Hypertensive disorders of in-vitro fertilization pregnancies: A study from Kosovo|
Vuniqi-Krasniqi, Merita; Paçarada, Myrvete; Daka, Qëndresë; Dervishi, Zeqir; Bimbashi, Astrit & Dakaj, Kushtrim
Background: Relationships between in-vitro fertilization (IVF), gestational
hypertension, and pregnancy outcomes are demonstrated in a number of studies.
However, it is still debated if IVF treatment or specific characteristics of infertile
patients are responsible for worse obstetrical and neonatal outcomes.
Objective: The aim of this study was to investigate maternal characteristics
associated with hypertensive disorders (HD) in IVF conceived pregnancies and to
assess the obstetrical and neonatal outcomes.
Materials and Methods: In this observational, cross-sectional study, 207 pregnant
women who underwent IVF treatment were consecutively divided into two groups: a
group that had no HD during pregnancy (IVF group) and a group that had HD
during pregnancy (IVF+HD group). Maternal, obstetrical and neonatal data of the
two groups were compared.
Results: Some maternal characteristics were significantly higher in IVF+HD
compared to IVF group such as: older age (p=0.0001), primiparity (p=0.038),
obesity (p=0.0001), and cigarette smoking (p=0.0001). There were no significant
differences between the groups in regard to obstetrical outcomes besides premature
rupture of membranes time that was significantly higher in IVF+HD group
compared to IVF group (p=0.036). In regard to neonatal outcomes, the only
statistically significant difference was in the 5th min Apgar score, which was higher
in IVF+HD group compared to IVF group without HD (p=0.002).
Conclusion: With regard to significantly higher differences in maternal
characteristics of IVF conceived pregnancies complicated with HD, compared to
uncomplicated ones, development of a specific national prevention measure for HD
of IVF conceived pregnancies in Kosovo is strongly suggested. In addition, setting
up of a national registry is recommended in order to evaluate the outcomes of IVF
In vitro fertilization; Gestational hypertension; Outcomes; Kosovo.