International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
Vol. 16, No. 1, 2018, pp. 51-56
Bioline Code: rm18007
Full paper language: English
Document type: Research Article
Document available free of charge
International Journal of Reproductive BioMedicine, Vol. 16, No. 1, 2018, pp. 51-56
© Copyright 2018 - International Journal of Reproductive BioMedicine
Trans dermal estrogen (oestrogel) for endometrial preparation in freeze embryo transfer cycle: An RCT|
Tehraninejad, Ensieh Shahrokh; Kabodmehri, Roya; Rashidi, Batol Hosein; Jafarabadi, Mina; Keikha, Fateme; Masomi, Masomeh & Hagholahi, Fedieh
Background: Estrogen and progesterone are two crucial factors for endometrial
preparation in frozen embryo transfer (FET) cycles. Studies assessing different
forms of estradiol in FET have published already but literature lacks enough surveys
on transdermal estrogen application in reproductive medicine.
Objective: To investigate the effects of trans dermal estrogen (Oestrogel) on
pregnancy rates in patients that candidate for FET cycle.
Materials and Methods: In this randomized clinical trial, 100 women undergoing
FET cycles referred to Imam Khomeeini Hospital were enrolled in two groups,
randomly. Group I received 8 mg/day estradiol valerate (E2 tablet) orally and group
II were treated with 6 mg/day transdermal oestrogel gel after suppression with
gonadotropin releasing hormone agonist. In both groups medication were started in
the first day of menstruation cycle and continued until endometrial thickness reached
8 mm. Pregnancy rates (chemical, clinical, and ongoing), abortion rate, live birth
rate, and frequency of complications were compared between two groups.
Results: Chemical and clinical pregnancy rates were not significantly different
between two groups (p=0.384). The abortion rate was significantly lower in group II
than group I (p=0.035). Ongoing pregnancy and the live birth rates were
significantly higher in group II (p=0.035). The rate of complication was not different
in two groups.
Conclusion: Oestrogel seems to enhance ongoing pregnancy and live birth rates in
comparison to estradiol valerate tablet.
FET cycle; Transdermal estrogen; Estradiol valerate GnRH analogue.
Alternative site location: http://www.ijrm.ir