Serum heat shock protein 70 in preeclampsia and normal pregnancy: A systematic review and meta-analysis|
Saghafi, Nafiseh; Pourali, Leila; Ghanbarabadi, Vahid Ghavami; Mirzamarjani, Fatemeh & Mirteimouri, Masoumeh
Background: Preeclampsia, a severe complication of human pregnancy is one of
the main causes of maternal, fetal, and neonatal morbidity and mortality with
unclear pathogenesis. Heat shock protein 70 (HSP70) is one of the factors that can
mediate cytoprotective, antiapoptotic, and immune regulatory effects.
Objective: This meta-analysis was performed with aim to evaluate HSP70 in
preeclampsia and normal pregnancy.
Materials and Methods: The original publications reporting the serum HSP70
levels in preeclampsia and normal pregnancies published before November 2015
were identified by searching PubMed Central, Scopus, and ISI Web of Knowledge
databases by two researchers, separately. The keywords were” preeclampsia” and
“HSP70” or “Heat shock protein 70” Statistical analyses were performed using
STATA software (version 11).
Results: Out of 127 studies, seven eligible case-control studies were identified
which consists of 350 preeclampsia and 429 normal pregnancies. Our pooled
analysis of data from 7 studies which met the inclusion criteria, provides evidence
that there is a significant association between HSP70 and preeclampsia. Cochran's
test results showed the heterogeneity of the studies (p<0.001) and the I2 index was
91%. The standardized mean differences (SMD) based on a random effect model
with trim and fill method was 0.92 (95% CI: 0.33-1.51); also there was a significant
association between HSP70 and preeclampsia (Z=3.07, p=0.002).
Conclusion: The results showed that serum HSP70 concentration was significantly
higher in preeclamptic patients than the control group. Therefore HSP70 may be
identified as a diagnostic factor.
Heat shock protein 70 (HSP70); Preeclampsia; Pregnancy; Meta-analysis