International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
Vol. 15, No. 10, 2017, pp. 635-640
Bioline Code: rm17075
Full paper language: English
Document type: Research Article
Document available free of charge
International Journal of Reproductive BioMedicine, Vol. 15, No. 10, 2017, pp. 635-640
© Copyright 2017 - International Journal of Reproductive BioMedicine
The effect of vitamin E and aspirin on the uterine artery blood flow in women with recurrent abortion: A single-blind randomized controlled trial|
Mesdaghinia, Elaheh; Mohammad-Ebrahimi, Behnaz; Foroozanfard, Fatemeh & Banafshe, Hamid Reza
Background: Recurrent spontaneous abortion has high incidence rate. The etiology
is unknown in 30-40%. However high uterine artery resistance is accounted as one
of the recurrent abortion reasons.
Objective: The objective of the current study was to determine the impacts of
vitamin E and aspirin on the uterine artery blood flow in women having recurrent
abortions due to impaired uterine blood flow.
Materials and Methods: This randomized clinical trial was conducted on 99
women having uterine pulsatility index (PI) more than 2.5 and the history of more
than two times abortions. The candidates were categorized into three groups;
receiving aspirin, only vitamin E, and aspirin+vitamin E. After 2 months, uterine PIs
were compared with each other.
Results: All drug regimens caused an enhancement in uterine perfusion with a
significant decline in uterine artery PI value. The women receiving vitamin E in
accompanied with aspirin had the least mean PI of the uterine artery (p<0.001). The
total average PI score of the right and left uterine arteries in groups receiving
vitamin E in accompanied with aspirin was lower than the two counterparts
Conclusion: Vitamin E, aspirin and especially their combination are effective in
improving uterine artery blood flow in women with recurrent abortion due to
impaired uterine blood flow. More well-designed studies are needed to find out
whether the enhancement of uterine perfusion may lead to a better pregnancy
Recurrent abortion; Aspirin; Vitamin E; Pulsatility index.
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