CXC Ligand 5 cytokine serum level in women with polycystic ovary syndrome and normal body mass index: A case-control study|
Zohrabi, Marzieh; Rahmani, Elham; Motamed, Niloofar & Akbarzadeh, Samad
Background: Polycystic ovary syndrome (PCOS) is the most common endocrine
disease and associated with insulin resistance. CXC Ligand 5 (CXCL5) is a new
cytokine which is secreted from white adipose tissue during obesity and by blocking
insulin signaling pathway inhibits the activity of insulin and promotes insulin
Objective: The aim of this study was to assess serum level of CXCL5 in PCOS
women with normal body mass index.
Materials and Methods: In this case-control study, 30 PCOS women with normal
body mass index as the case group and 30 non-PCOS women as the controls were
enrolled. Serum levels of CXCL5, insulin and other hormones factors related with
PCOS were measured by ELISA method, also the biochemical parameters were
measured by autoanalyzer.
Results: Significant increases in serum insulin concentration, homeostasis model
assessments of insulin resistance, luteinizing hormone, luteinizing hormone/follicle-stimulating
hormone, fasting blood sugar, testosterone, and prolactin were observed
in the case group compared to the controls. were in the serum level of CXCL5,
cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol,
dehydroepiandrosterone-sulfate, creatinine, and homeostasis model
assessment of beta cell function between these two groups.
Conclusion: In this study, no significant change was observed in serum
concentrations of CXCL5 in PCOS women with normal BMI.
Polycystic ovary syndrome, Insulin resistance, CXCL5 cytokine, Hyperinsulinemia, Hyperandrogenism.