International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
Vol. 15, No. 9, 2017, pp. 569-574
Bioline Code: rm17067
Full paper language: English
Document type: Research Article
Document available free of charge
International Journal of Reproductive BioMedicine, Vol. 15, No. 9, 2017, pp. 569-574
© Copyright 2017 - International Journal of Reproductive BioMedicine
Relationship between human leukocyte antigen (HLA)-DQA1*0102/HLA-DQB1*0602 polymorphism and preeclampsia|
Mohammadi, Mahmoud; Farazmandfar, Touraj & Shahbazi, Majid
Background: Preeclampsia is a condition associated with systemic disorders in the
mother and the fetus. However, the exact causes of preeclampsia are unknown, but
several genetics and environmental factors play role in development of this disease.
Major histocompatibility complex role is very important during pregnancy through
which the fetus is not rejected by mother’s immune system.
Objective: In this study, we investigated the relationship of the human leukocyte
antigen (HLA)-DQA1*0102/HLA-DQB1*0602 polymorphism with preeclampsia.
Materials and Methods: Genomic DNA of 181 pregnant women with a history of
preeclampsia as the case group and 228 pregnant women with no history of
preeclampsia as the controls were extracted. The HLA-DQA1*0102/HLA-DQB1*
0602 polymorphisms of all DNA samples were identified by the SSP-PCR
method. Frequencies difference of variables between case and control groups were
calculated by Chi-square test. The ethnic origin of the participants in this study was
extracted from their medical records.
Results: There was a significant association between preeclampsia and Sistani
ethnic group (p=0.031). Moreover, there was a significant association between
preeclampsia and frequencies of allele HLA-DQB1*0602 (p<0.001), and genotypes
of heterozygote (+0102/-0602) (p<0.001) and negative homozygote (-0102/-0602)
(p=0.005). There also was an association between allele HLA-DQB1*0602 and
preeclampsia in Fars ethnic group (p=0.028).
Conclusion: It seems that immune incompatibility may have an important role in
preeclampsia predisposition. According to our results, the lack of locus HLA-DQB1*0602 may be a risk factor for preeclampsia.
Preeclampsia; HLA-DQ; Genotyping.
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