Comparison of the effects of Ginger extract with clomiphene citrate on sex hormones in rats with polycystic ovarian syndrome|
Atashpour, Shekoufeh; Jahromi, Hossein Kargar; Jahromi, Zahra Kargar & Maleknasab, Mozhgan
Background: Polycystic ovarian syndrome (PCOS) is the most common endocrine
disorder in women which affect fertility. Clomiphene citrate is used as first-line
treatment for this disorder, which is associated with some complications and
Objective: In this research, we compare the effectiveness of ginger with clomiphene
on sexual hormones such as Luteinizing hormone (LH), Follicle-stimulating
hormone (FSH), estrogen and progesterone in order to treat PCOS effectively with
fewer side effects.
Materials and Methods: In this experimental study, 63 adult female rats (170-200
gr) were studied and divided randomly into 9 groups as control (not received any
interventional substance for 60 and 89 days), sham (were given distilled water and
ethyl alcohol intraperitoneally daily for 60 and 89 days), and 7 experimental groups
receiving estradiol valerate (PCOS inducing agent, intramuscular) alone and with
100 mg/kg clomiphene or different doses of ginger extract (175 and 350 mg/kg)
orally daily for 60 and 89 days. Sexual hormones were analyzed and compared in
Results: Our results showed that in the PCOS-induced group, LH and estrogen
concentration increased while progesterone and FSH concentration decreased
remarkably (p<0.05) as compared to control group. Furthermore, in groups receiving
clomiphene and ginger extract, we demonstrated significant (p<0.05) improvement in
hormonal secretion as compared to the PCOS-induced group. Clomiphene,
compared with the lower dose of ginger extract, had a better improving effect on
balancing sexual hormones in PCOS. Moreover, ginger extract at higher doses has
better effects in improving PCOS.
Conclusion: As the long-term administration of clomiphene citrate has some side
effects, the use of ginger as a herbal medicine without any side effects at high doses
can be an effective and good alternative in improving PCOS.
Ginger; Clomiphene citrate; Polycystic ovarian syndrome.