International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
Vol. 15, No. 7, 2017, pp. 447-452
Bioline Code: rm17057
Full paper language: English
Document type: Research Article
Document available free of charge
International Journal of Reproductive BioMedicine, Vol. 15, No. 7, 2017, pp. 447-452
© Copyright  - International Journal of Reproductive BioMedicine
Protective effects of curcumin co-treatment in rats with establishing chronic variable stress on testis and reproductive hormones|
Mohamadpour, Masoomeh; Noorafshan, Ali; Karbalay-Doust, Saied; Talaei-Khozani, Tahereh & Aliabadi, Elham
Background: Protracted and repeated exposure to chronic variable stress (CVS)
may lead to reproductive dysfunction. It is a basic cause of male infertility.
Curcumin (CUR) is an active fraction of turmeric that used in traditional Chinese
medicine. CUR represents various pharmacological activities.
Objective: The purpose of this study was to determining the effects of CUR on
testis and testosterone, follicle stimulating hormone (FSH) and luteinizing hormone
(LH) in rats with establishing chronic variable stress.
Materials and Methods: Twenty-one adult male Sprague-Dawley rats were divided
into three groups: 1) control, 2) CVS and 3) CVS+ CUR (100 mg/kg/day dissolved
in 0.5 mL of olive oil). All of the animals in control, CVS, and CVS+CUR groups
were sacrificed after 15 days. Testosterone, FSH, LH, and testis damage were
Results: Significant changes in the normal range of testosterone, FSH, LH serum
levels and seminiferous tubule apoptotic cells were detected in CVS group compared
to the control rats (p=0.02). These parameters changed to a less extent in CVS+CUR
animals compared to the CVS rats (p=0.02).
Conclusion: Our findings propose that curcumin might have curative potential on
the reproductive system function and its impairment. It’s regulated by stress and
Testosterone; Follicle stimulating hormone; Luteinizing hormone; CVS; Curcumin.
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