International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
Vol. 15, No. 7, 2017, pp. 441-446
Bioline Code: rm17056
Full paper language: English
Document type: Research Article
Document available free of charge
International Journal of Reproductive BioMedicine, Vol. 15, No. 7, 2017, pp. 441-446
© Copyright  - International Journal of Reproductive BioMedicine
The effect of 24 hours delay in oocyte maturation triggering in IVF/ICSI cycles with antagonist protocol and not-elevated progesterone: A randomized control trial|
Davar, Robab; Naghshineh, Elham & Neghab, Nosrat
Background: The best time of final oocyte maturation triggering in assisted
reproduction technology protocols is unknown. This time always estimated by
combined follicular size and blood progesterone level.
Objective: The aim of this study was evaluation of the effect of delaying oocyte
maturation triggering by 24 hr on the number of mature oocytes (MII) and other in
vitro fertilization cycle characteristics in antagonist protocols with not-elevated
progesterone (p ≤1 ng/ml).
Materials and Methods: All patients' candidate for assisted reproduction
technology underwent controlled ovarian hyperstimulation by antagonist protocol.
When at least 3 follicles with ≥18 mm diameters were seen by vaginal
ultrasonography; blood progesterone level was measured. The patients who had
progesterone level ≤1 ng/dl entered the study. The participants' randomizations were
done and patients were divided into two groups. In the first group, final oocyte
maturation was done by human chorionic gonadotropin at the same day, but in the
second group, this was performed 24 hr later. Oocytes retrieval was done 36 hr after
human chorionic gonadotropin trigger by transvaginal ultrasound guide.
Results: Number of retrieved oocytes, mature oocytes (MII), fertilized oocytes
(2PN), embryos formation, number of transferred embryos and embryos quality has
not significant differences between two groups. Also, fertilization and implantation
rate, chemical and clinical pregnancy did not differ between groups.
Conclusion: Delaying of triggering oocyte maturation by 24 hr in antagonist
protocol with not-elevated progesterone (progesterone ≤1 ng/ml) have not beneficial
nor harmful effect on the number of mature oocytes (MII) and other in vitro
fertilization cycle characteristics.
Assisted reproductive technologies; In vitro fertilization; Randomized controlled trial.
Alternative site location: http://www.ijrm.ir