International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
Vol. 15, No. 7, 2017, pp. 435-440
Bioline Code: rm17055
Full paper language: English
Document type: Research Article
Document available free of charge
International Journal of Reproductive BioMedicine, Vol. 15, No. 7, 2017, pp. 435-440
© Copyright  - International Journal of Reproductive BioMedicine
Controlled ovarian stimulation with r-FSH plus r-LH vs. HMG plus r-FSH in patients candidate for IVF/ICSI cycles: An RCT|
Tehraninejad, Ensieh Shahrokh; Taghinejad, Mina Farshbaf; Rashidi, Batool Hossein & Haghollahi, Fedyeh
Background: Different combination of gonadotropin preparation has been
introduced with no definite superiority of one over others in in vitro fertilization
(IVF), but individualized regimens for each patient are needed.
Objective: The aim of the present study was to investigate the effect of controlled
ovarian stimulation with recombinant- follicle stimulating hormone (r-FSH) plus
recombinant-luteinizing hormone (rLH) versus human menopausal gonadotropin
(HMG) plus r-FSH on fertility outcomes in IVF patients.
Materials and Methods: This is a randomized clinical trial study that was
performed from October 2014-April 2016 on 140 infertile patients with a set of
inclusion criteria that referred to infertility clinics in Vali- asr and Gandhi Hospital
in Tehran. The women were randomly divided into two treatment groups. The first
group (n=70) received rFSH from the second day of cycle and was added HMG in
6th day and the 2nd group (n=70), received rFSH from the second day of cycle and
was added recombinant-LH in 6th day. Then ovum Pick-Up and embryo transfer
were performed. In this study, we assessed the outcomes such as; chemical and
clinical pregnancy rate, live birth and abortion rate.
Results: Number of follicles in ovaries, total number of oocytes or M2 oocytes and
quality of fetuses has no significant differences between two groups (p>0.05). Total
number of fetuses were significantly higher in patients who received rFSH + HMG
(p=0.02). Fertility outcomes consisted of: live birth rate, chemical pregnancy and
clinical pregnancy rate were higher in rFSH + HMG group in comparison to rFSH
+r-LH group (p<0.05).
Conclusion: It seems that in IVF patients, HMG + rFSH used for controlled ovarian
hyperstimulation have better effects on fertility outcomes, but in order to verify the
results, it is recommended to implement studies on more patients.
Ovulation induction; Recombinant-FSH; Recombinant-LH; Human menopausal gonadotropin; IVF; ICSI
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