Association of leptin and insulin resistance in PCOS: A case-controlled study|
Jahromi, Bahia Namavar; Dabaghmanesh, Mohammad Hassan; Parsanezhad, Mohammad Ebrahim & Fatehpoor, Faranak
Background: Endocrine abnormalities related to polycystic ovary Syndrome
(PCOS) are important problems.
Objective: To compare serum leptin levels between infertile women with and
without PCOS. To rank sensitivity of six indirect methods for detection of insulin
resistance (IR) and to evaluate the association between leptin and IR in PCOS group.
Materials and methods: This Case-controlled study performed on 189 infertile
women referred to Shiraz Mother and Child Hospital during 2012-2015. Ninety-nine
PCOS cases according to Rotterdam criteria were compared to 90 cases without
PCOS. Serum leptin, body mass index (BMI), several hormones, and their
correlation coefficients with leptin were compared. IR in PCOS women was
measured by indirect methods, including fasting blood sugar (FBS), fasting insulin
(FI), glucose/insulin, homeostatic model assessment of insulin resistance (HOMA-IR),
quantitative insulin sensitivity check index (QUICKI), and MacAuley index.
Association between IR and leptin was evaluated. Independent sample t-test and
Pearson’s test were used.
Results: Infertile women with PCOS had higher BMI (26.47±3.62 vs. 24.82±5.18
kg/m2) and serum leptin levels (41.79±187.89 vs. 19.38±12.57 ng/mL). Leptin
showed significant association with weight and BMI in both groups (p<0.001) and
to age in non-PCOS group. HOMA-IR showed the highest rate of IR followed by FI
and QUICKI methods. The mean leptin levels had positive association with IR
assessed by HOMA-IR (p<0.001), QUICKI (p<0.001), FI (p=.002), and FBS
Conclusion: BMI and IR have positive association with serum leptin in PCOS
infertile women. HOMA-IR followed by FI and QUICKI is the most sensitive test
for detection of IR.
Leptin; Polycystic ovarian syndrome; Infertility; Insulin resistance.