International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
Vol. 15, No. 6, 2017, pp. 345-350
Bioline Code: rm17045
Full paper language: English
Document type: Research Article
Document available free of charge
International Journal of Reproductive BioMedicine, Vol. 15, No. 6, 2017, pp. 345-350
© Copyright 2017 - International Journal of Reproductive BioMedicine
Evaluation of vitamin D status and its correlation with oxidative stress markers in women with polycystic ovary syndrome|
Rahsepar, Maryam; Mahjoub, Soleiman; Esmaeilzadeh, Sedigheh; Kanafchian, Maryam & Ghasemi, Maryam
Background: There is little evidence about antioxidant properties of vitamin D.
Recent studies suggest that oxidative stress may play a major role in the
pathophysiology of polycystic ovary syndrome (PCOS), but the association of
vitamin D with oxidative stress is still not known in PCOS.
Objective: The goal of the present study was to evaluate the correlation between
serum 25-hydroxy vitamin D and oxidative stress markers in PCOS group compared
to control group.
Materials and Methods: 60 PCOS women (20-40 yr old) and 90 healthy women as
control group were participated in this case-control study. Fasting serum level of 25-hydroxy vitamin D 25(OH) D, glucose, insulin, calcium, malondialdehyde (MDA),
protein carbonyl (PC), also homeostasis model assessment for insulin resistance
(HOMA-IR) and fasting glucose to insulin ratio (FGIR) were measured.
Results: It was found that the mean of serum 25(OH)D was lower in the PCOS
group (10.76±4.17) than in the control group (12.07±6.26) but this difference was
not statistically significant (p=0.125). Fasting insulin, HOMA-IR and MDA were
significantly higher in the PCOS patients as compared to the controls, whereas PC
level did not differ for the two groups (p=0.156). No significant correlations were
found between 25(OH) D levels and oxidative stress markers (MDA and PC).
Conclusion: The findings indicated no significant differences in the serum 25(OH)
D levels between the PCOS patients and the matched controls. Also, no correlation
was found between the serum vitamin D levels and oxidative stress markers in both
Polycystic ovary syndrome; Vitamin D; Oxidative stress; Malondialdehyde
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