The effects of multi mineral-vitamin D and vitamins (C+E) supplementation in the prevention of preeclampsia: An RCT|
Azami, Milad; Azadi, Tayebe; Farhang, Sepidezahra; Rahmati, Shoobo & Pourtaghi, Khadijeh
Background: Several studies have reported the uncertain role of multi-minerals and
vitamins in the prevention of preeclampsia.
Objective: The present study aims to investigate the effect of multimineral-vitamin
D supplements (calcium, magnesium, zinc and Vitamin D) and vitamins (C+ E) in
the prevention of preeclampsia.
Materials and Methods: In this randomized clinical trial, 90 pregnant women were
divided into three groups: group A received Ferrous sulfate (1 tablet/day) + one
tablet of Claci-care multimineral-vitamin D containing 800mg calcium, 200mg
magnesium, 8mg zinc and 400 IU Vitamin D3 per day; group B received Ferrous
sulfate (1 tablet/day) + 250 mg vitamin C + 55 mg vitamin E; and the controls
received only one Ferrous sulfate tablet daily.
Results: The incidence of preeclampsia in group A was significantly lower than the
control group (p=0.03), while there was no significant difference between group B
and controls (p=0.50), as well as groups A and B (p=0.063). The incidence of
neonatal complications in the group A was significantly lower than the control group
(p=0.01), while there was no significant difference between group B and control
Conclusion: According to the results, calcium, magnesium, and zinc supplements
have a significant effect on the prevention of preeclampsia. In addition, prescription
of multimineral-vitamin D during pregnancy can be a low-cost and affordable way
to reduce the incidence of preeclampsia in women who are at high risk of
Prevention; Preeclampsia; Calcium; Magnesium; Zinc; Vitamin D; Vitamin C; Vitamin E.