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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433
EISSN: 2008-2177
Vol. 15, No. 4, 2017, pp. 203-208
Bioline Code: rm17027
Full paper language: English
Document type: Research Article
Document available free of charge

International Journal of Reproductive BioMedicine, Vol. 15, No. 4, 2017, pp. 203-208

 en N-acetyl cysteine in ovulation induction of PCOS women underwent intrauterine insemination: An RCT
Lak, Tahereh Behrouzi; Hajshafiha, Masoomeh; Nanbakhsh, Fariba & Oshnouei, Sima


Background: N-acetyl cysteine (NAC) was proposed as an adjuvant to clomiphene citratefor ovulation induction in patients with polycystic ovary syndrome (PCOS) without clomiphene citrate resistance.
Objective: To evaluate the effect of NAC on pregnancy rate in PCOS patients who were candidates for intrauterine insemination.
Materials and Methods: In this randomized clinical trial 97 PCOS women aged 18-38 years were enrolled in two groups, randomly. For the case group (n=49), NAC (1.2 gr)+ clomiphene citrate (100 mg) + letrozole (5mg) were prescribed Daily from the third day of menstruation cycle for five days. The control group (n=48) had the same drug regimen without NAC. In order to follicular development, GONALF was injected on days of 7-11 menstrual cycles in all participants. When the follicle size was 18mm or more, HCG (10000 IU) was injected intramuscular and the intrauterine insemination was performed after 34-36 hr.
Results: There were not significant differences between study groups regarding mean endometrial thickness (p=0.14), mean number of mature follicles (p=0.20) and the pregnancy rate (p=0.09).
Conclusion: NAC is ineffective in inducing or augmenting ovulation in PCOS patients who were candidates for intrauterine insemination and cannot be recommended as an adjuvant to CC in such patients.

N-acetyl cysteine; Polycystic ovary syndrome; Intrauterine insemination; Ovulation induction

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