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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433
EISSN: 2008-2177
Vol. 14, No. 9, 2016, pp. 603-606
Bioline Code: rm16078
Full paper language: English
Document type: Case Report
Document available free of charge

International Journal of Reproductive BioMedicine, Vol. 14, No. 9, 2016, pp. 603-606

 en Fertility sparing surgery in gestational trophoblastic neoplasia: A report of 4 cases
Hasanzadeh, Malihe; Roodsari, Ftemeh Vahid; Ahmadi, Shahnaz; Mehr, Masoumeh Gavedan & Azadeh, Tabari


Background: Gestational trophoblastic neoplasia (GTN) is a curable disease that involves the development of malignant tumor in the woman after a normal or molar pregnancy. The position of surgery in GTN is not properly specified and is changing due to new chemotherapy protocols. However, the role of surgery is highlighted in chemotherapy-resistant GTN. Other indications of surgery in trophoblastic diseases are drug toxicity and uterine perforation. Based on the fact that most women in certain age tend to preserve fertility, this study reported 4 cases of successful treatment after fertility sparing surgery.
Case: A hospital-based case-report study was carried out to investigate the role of surgery in 4 patients with GTN. In this study, acute complications, such as intraabdominal bleeding and liver dysfunction due to chemotherapy occurred in some patients. Surgery was performed and all cases underwent localized tumor removal while preserving the uterus. No hysterectomy surgery was performed.
Conclusion: Surgery is supposed in specific cases of GTN, who desire preserving fertility.

GTT; Fertility; Surgery; Chemotherapy

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