International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
Vol. 14, No. 6, 2016, pp. 421-426
Bioline Code: rm16054
Full paper language: English
Document type: Research Article
Document available free of charge
International Journal of Reproductive BioMedicine, Vol. 14, No. 6, 2016, pp. 421-426
© Copyright 2016 - Iranian Journal of Reproductive Medicine
Association between PAPP-A and placental thickness|
Mesdaghi-nia, Elaheh; Behrashi, Mitra; Saeidi, Arezoo; Kalahroudi, Masoumeh Abedzadeh & Sehat, Mojtaba
Background: Measuring of maternal serum pregnancy-associated plasma protein-A
(PAPP-A) in first trimester can be a way for early detection of adverse prenatal
outcome due to faulty placenta.
Objective: The aim was to Determination of association between placental
thickness in second trimester with low level of PAPP-A in first trimester.
Materials and Methods: In this cohort study, serum PAPP-A of 187 pregnant
women was measured in the first trimester of pregnancy. Patients who had PAPP-A
≤0.8 MOM were in exposed and others who had PAPP-A >0.8 defined as unexposed
group. The criteria of placental thickness in ultrasound study was thickness of 4 cm
or more than 50% of placental length.
Results: Of 187 patients, 87 patients had PAPP-A >0.8 and 93 patients had PAPP-A
≤0.8. Women with low levels of PAPP-A in the first trimester, had an increased
incidence placental thickness of 34.4%, whereas another group had about 15%
(p=0.002). Also, PAPP-A levels had acceptable sensitivity and specificity for
placental thickness detection (71.1% and 54.8%, respectively.
Conclusion: Our study showed that serum level of PAPP-A generally was low
(≤0.8) in women with a thick placenta (>4 cm or >50% of placental length). The
first trimester of pregnancy measurement of PAPP-A will be more predictable for
Pregnancy-associated plasma protein-A (PAPP-A); Pregnancy; Placenta
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