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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433
EISSN: 2008-2177
Vol. 11, No. 11, 2013, pp. 891-898
Bioline Code: rm13113
Full paper language: English
Document type: Research Article
Document available free of charge

International Journal of Reproductive BioMedicine, Vol. 11, No. 11, 2013, pp. 891-898

 en Effects of Fumaria parviflora check for this species in other resources leaves extract on reproductive parameters in adult male rats
Dorostghoal, Mehran; Seyyednejad, Seyyed Mansoor; Khajehpour, Lotfollah & Jabari, Ayoob


Background: There is growing concern that occupational, environmental and lifestyle factors adversely affect male reproductive health. Fumaria parviflora check for this species in other resources Lam. is being used traditionally in Persian folk medicine to cure various ailments and has been supposed to have fertility-enhancing properties.
Objective: A dose-response study was designed to assess effects of F. parviflora ethanolic leaves extract on reproductive parameters in adult male Wistar rats.
Materials and Methods: In this experimental study, healthy adult male rats were treated with 100, 200 and 400 mg/kg/day of F. parviflora leaves extract via gavage for 70 days. Blood samples were collected for determination of testosterone, LH and FSH serum levels. Reproductive organs weight, motility, morphology and density of epididymal sperm, seminiferous tubules diameter and germinal epithelium height were evaluated in each experimental group.
Results: The body weight was not affected, while the weights of testis and epididymis were significantly enhanced in rats treated with 200 and 400 mg/kg/day F. parviflora extract. No significant changes were observed in seminal vesicle and ventral prostate weight between experiment groups. Significant increase was found in epididymal sperm density and percent of morphologically normal sperm in extract-treated rats. Serum testosterone levels were significantly higher in rats received 200 and 400 mg/kg/day.
Conclusion: The results indicated that ethanolic extract of F. parviflora leaves have a potential to improve reproductive parameters and enhance male fertility.

Fumaria parviflora Lam.; Male fertility; Spermatogenesis; Sperm quality; Testosterone

© Iranian Journal of Reproductive Medicine
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