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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433
EISSN: 2008-2177
Vol. 11, No. 9, 2013, pp. 711-716
Bioline Code: rm13089
Full paper language: English
Document type: Research Article
Document available free of charge

International Journal of Reproductive BioMedicine, Vol. 11, No. 9, 2013, pp. 711-716

 en Effects of glycowithanolides on lipid peroxidation and lipofuscinogenesis in male reproductive organs of mice
Walvekar, Madhuri; Shaikh, Nilofar & Sarvalkar, Priti


Background: Glycowithanolides (Withaferin A), is one of the main withanolides active principle isolated from plant Withania somnifera check for this species in other resources and is claimed that it possess the aphrodisiac, sedative, rejuvenate and life prolonging properties.
Objective: In the present investigation, antioxidant activity of active principles of Withania somnifera was tested against D-galactose induced oxidative stress in mouse testes, epididymis and seminal vesicle.
Materials and Methods: For the present investigation Swiss male albino mice Mus musculus (Linn) were used. They were grouped in to control (I), D-galactose treated (II), protective (III) and curative groups (IV). Oxidative stress was induced in six month old mice by injecting a low dose of D-galactose. Antioxidant effect of plant extract was studied in testes, epididymis, and seminal vesicle of oxidative stressed mice on Lipid peroxidation (LPO) and fluorescence product.
Results: In the present study, both total as well as mitochondrial lipid peroxidation and fluorescence product in testes, epididymis and seminal vesicle were increased in D-galactose induced mice. After the treatment of glycowithanolides there was significantly decrease in total as well as mitochondrial lipid peroxidation and fluorescence product in protective and curative groups.
Conclusion: Our results indicate that Withania somnifera has a capability of preventing oxidative stress and also combating stress induced infertility.

Withania somnifera; Antioxidant; Lipid peroxidation; Cytoplasmic granules; Testes; Epididymis; Seminal vesicle

© Iranian Journal of Reproductive Medicine
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