International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
Vol. 11, No. 1, 2013, pp. 61-64
Bioline Code: rm13009
Full paper language: English
Document type: Research Article
Document available free of charge
International Journal of Reproductive BioMedicine, Vol. 11, No. 1, 2013, pp. 61-64
© Copyright 2013 - Iranian Journal of Reproductive Medicine
Case control study of the factor V Leiden and factor II G20210A mutation frequency in women with recurrent pregnancy loss|
Ardestani, Majid Teremmahi; Nodushan, Hossein Hadi; Aflatoonian, Abbas; Ghasemi, Nasrin & Sheikhha, Mohammad Hasan
Background: Recurrent pregnancy loss (RPL) caused by various genetic and non-genetic factors. After chromosome abnormality, thrombophilia is one of the most important genetic factors that could cause RPL. Factor V Leiden and factor II G20210A mutation were the most common mutations cause thrombophilia in the world.
Objective: The purpose of this study was to determine the frequency of factor V Leiden and prothrombine gene mutations in women with RPL compared with women who had uneventful pregnancies.
Materials and Methods: This case control study evaluates the frequency of factor V-Leiden and factor II G20210 genotypes in 80 women with two or more pregnancy losses, compared with 80 women without adverse pregnancy outcome. The mutations were assessed by PCR-RFLP.
Results: Frequency of the factor V Leiden among cases was 2.5%, which was higher than controls (1.25%), but the difference was not significant. No factor II G20210 mutation was found among cases and controls.
Conclusion: These data did not confirm that factor V Leiden and factor II G20210 mutation might play a role in recurrent pregnancy loss in Iranian women.
Factor V Leiden, Factor II G20210A Mutation, Recurrent Abortion
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