International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
Vol. 9, No. 3, 2011, pp. 193-198
Bioline Code: rm11029
Full paper language: English
Document type: Research Article
Document available free of charge
International Journal of Reproductive BioMedicine, Vol. 9, No. 3, 2011, pp. 193-198
© Copyright 2011 Iranian Journal of Reproductive Medicine.
Correlation between the level of cholesteryl ester transfer protein in follicular fluid with fertilization rates in IVF/ICSI cycles|
Mehdizadeh, Amir; Rahimipour, Ali; Farzadi, Laya; Darabi, Masoud; Shahnazi, Vahideh; Shaaker, Maghsod; Vatankhah, Amir-Mansour; Golmohamadi, Zahra & Nouri, Mohammad
Background: Follicular fluid (FF) plays an important role in oocytes and embryo development, which may contribute to IVF/ICSI success rate.
Objective: The aim of this study was to investigate the correlation between cholesteryl ester transfer protein (CETP) level in FF and the success rate of IVF/ICSI.
Materials and Methods: In a cross-sectional study, FF samples, FF samples were obtained from 100 patients referred to Tabriz Alzahra Hospital. Seventy-nine subjects underwent IVF and the remaining 21 underwent ICSI. The levels of high-density lipoprotein cholesterol (HDL-C), apolipoprotein A-I and CETP were measured using enzymatic, turbidometric and ELISA methods respectively.
Results: Analysis of the subgroups with different levels of CETP showed a significant lower level of CETP in the subgroup with the lowest number of mature oocytes (p<0.05). The level of CETP was also considerably lower (18%, p=0.05) in subjects with<50% oocytes fertilization ratio than subjects with >70% of this ratio.
Conclusion: While no association was found for pregnancy, the amount of CETP in FF was associated positively to the maturity and the percentage of oocyte fertilization.
Infertility, IVF/ICSI, Apolipoprotein A-I, CETP.
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