International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
Vol. 8, No. 3, 2010, pp. 95-100
Bioline Code: rm10018
Full paper language: English
Document type: Research Article
Document available free of charge
International Journal of Reproductive BioMedicine, Vol. 8, No. 3, 2010, pp. 95-100
© Copyright 2010 - Iranian Journal of Reproductive Medicine
The Leptin concentrations in seminal plasma of men and its relationship to semen parameters|
Jorsaraei, Seyed Gholam Ali; Shibahara, Hiroaki; Ayustawati; Hirano, Yuki; Suzuki, Tatsuya; Marzony, Eisa Tahmasbpour; Zainalzadeh, Mahtab & Suzuki, Mitsuaki
Background: Leptin is a polypeptide hormone secreted by white adipose tissue in proportion to body energy. Although the participation of leptin in female reproduction is well established, any role in male reproductive function is at best tenuous.
Objective: The objective of this study was to compare the leptin concentration in human seminal plasma and then the relationships between seminal leptin and semen parameters were evaluated.
Materials and Methods: Semen samples were provided from 71 men; normozoospermic (n=22), asthenozoospermic (n=31) and oligoasthenozoospermic (n=18) referring to Jichi Medical University Hospital for in vitro fertilization-embryo transfer (IVF-ET) treatment. After liquefaction, all sperm specimens were evaluated for sperm parameters and motility characteristics by computer-assisted semen analysis (CASA) system. After semen analysis, concentrations of leptin in seminal plasma of all groups were measured by ELISA.
Results: The mean concentrations of leptin in seminal plasma of normozoospermic, asthenozoospermic and oligoasthenozoospermic men were 0.75+/-0.09 ng/ml, 0.8+/-0.14 ng/ml and 0.8+/-0.15 ng/ml, respectively. A trend was observed for a lower leptin concentration in seminal plasma of normozoospermic men compared with asthenozoospermic and oligoasthenozoospermic men. There was a significant negative correlation between seminal plasma leptin concentration with sperm motility (p<0.05) and Curvilinear Velocity of the sperm kinetic parameter (p<0.01).
Conclusion: It was demonstrated that there was a significant correlation between seminal leptin with the sperm motility.
Leptin, Sperm quality, Male infertility, Seminal plasma, Fertilization rate.
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