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International Journal of Reproductive BioMedicine
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences of Yazd
ISSN: 1680-6433
EISSN: 2008-2177
Vol. 5, No. 2, 2007, pp. 57-60
Bioline Code: rm07013
Full paper language: English
Document type: Research Article
Document available free of charge

International Journal of Reproductive BioMedicine, Vol. 5, No. 2, 2007, pp. 57-60

 en CA-125 in normal pregnancy and threatenedabortion
Sedigheh Ayaty; Fatemeh Vahid Roudsari & Fatemeh Tavassoly


Background: CA-125 is a glycoprotein and its origin is uncertain during pregnancy. It arises during the first trimester and return to a non-pregnancy range in late pregnancy.
Objective: The aim of this study was to compare CA-125 level in threatened abortion and normal pregnancy less than 20 weeks of pregnancy.
Materials and Methods: This was a prospective case study carried out on 50 healthy pregnant (group 1) and 50 threatened abortion women (group 2). We compared the levels of CA-125 in these groups and followed them to be informed of the outcome of pregnancy.
Results: Fifty percent of women were in 20-24 years old group, primigravida and in the first trimester of pregnancy. The mean level of CA-125 in group 1 was 26.2 ± 3.25 IU/ml and in group 2 was 37.44 ± 2.72 IU/ml. The mean level of CA-125 in finally aborted patients was 58.17±7.25 IU/ml and in normal pregnant women, who continue to term, was 26.61±1.76 IU/ml. The CA-125 level in threatened women,whose pregnancy continued and did not abort, was 30.89 IU/ml. There was statistically significant difference between mean serum CA-125 levels of two groups (p < 0.05), while there was no statistically significant difference between these levels in the patients of both groups who continued pregnancies (p > 0.1). In group 2, there was a statistically significant difference in the level of CA-125 between those who developed abortion and those whose pregnancy continued but not aborted (p < 0.05).
Conclusion: Measurement of serum CA-125 may be an inexpensive, easily available, sensitive and specific predictor of outcome in threatened abortion, which results the loss of pregnancy.

CA-125, Pregnancy, Abortion, Threatened abortion.

© Copyright 2007 - Iranian Journal of Reproductive Medicine
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